| 书目名称 | Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scatter | | 编辑 | Kiyotaka Akabori | | 视频video | | | 概述 | Nominated by Carnegie Mellon University as an outstanding PhD Thesis.Describes the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems.Presents th | | 丛书名称 | Springer Theses | | 图书封面 |  | | 描述 | .This Thesis in biological physics has two components, describing the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems..The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-1 virus. Although highly positively charged, the Tat protein has been shown to translocate through hydrocarbon lipid bilayers easily, without requiring the cell’s energy, which is counter to its Born self-energy. In this work Tat’s location in the headgroup region was demonstrated using a combined X-ray scattering and molecular dynamics approach. Bilayer thinning was observed as well as softening of different membrane mimics due to Tat. It was concluded that Tat’s headgroup location, which increases the area/lipid, and its bilayer softening likely reduce the energy barrier for passive translocation..The second part is a rigorous investigation of an enigmatic phase in the phase diagram of the lipid dimyristoylphosphatidylcholine (DMPC). The ripple phase has fascinated many researchers in condensed matter physics and physical chemistry as an example of periodically modulated phases, with | | 出版日期 | Book 2015 | | 关键词 | Bilayer thinning; DMPC ripple phase; Fuid phase membranes; HIV-1 Tat peptide; Lipid bilayers; Molecular d | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-22210-3 | | isbn_softcover | 978-3-319-37047-7 | | isbn_ebook | 978-3-319-22210-3Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | Springer International Publishing Switzerland 2015 |
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发表于 2025-3-21 18:41:38
