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Titlebook: Stress-Activated Protein Kinases; Francesc Posas,Angel R. Nebreda Book 20081st edition Springer-Verlag Berlin Heidelberg 2008 Activation.C

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书目名称Stress-Activated Protein Kinases
编辑Francesc Posas,Angel R. Nebreda
视频video
概述Discusses the mechanisms underlying the function of SAPKs and the relevance of these signalling pathways in different organisms.Written by international experts.Includes supplementary material:
丛书名称Topics in Current Genetics
图书封面Titlebook: Stress-Activated Protein Kinases;  Francesc Posas,Angel R. Nebreda Book 20081st edition Springer-Verlag Berlin Heidelberg 2008 Activation.C
描述.To maximize the probability of survival, cells need to coordinate their intracellular activities in response to changes in the extracellular environment. MAP kinase cascades play an important role in the transduction of signals inside eukaryotic cells. In particular, stress stimuli result in the rapid activation of a highly conserved group of MAP kinases, known as SAPKs (Stress-Activated Protein Kinases). These kinases coordinate the generation of adaptive responses that are essential for cell survival, which include the modulation of several aspects of cell physiology from metabolism to gene expression...In this book, leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signalling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signalling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. .
出版日期Book 20081st edition
关键词Activation; Cell Cycle Regulation; Kinase; Phosphorylation; Signalling; Stress Adaptation; Stress Response
版次1
doihttps://doi.org/10.1007/978-3-540-75569-2
isbn_softcover978-3-642-09480-4
isbn_ebook978-3-540-75569-2Series ISSN 1610-2096 Series E-ISSN 1610-6970
issn_series 1610-2096
copyrightSpringer-Verlag Berlin Heidelberg 2008
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Topics in Current Geneticshttp://image.papertrans.cn/s/image/879643.jpg
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,Intrinsically Active (MKK-Independent) Variants of SAPKs – How do They Work?,s for increasing their activity. We suggest that this process emulates the naturalmechanism of p38 activation, achieved via phosphorylation of Tyr323 (the “bypass” pathway).This notion suggests that the intrinsically active mutants are legitimate for biological studies.
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