| 书目名称 | Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules |
| 编辑 | Robert.J Sharpe |
| 视频video | |
| 概述 | Includes detailed figures and schemes in each chapter and subsection to make the thesis easy to follow and understand.Provides extensive and thorough procedural and analytical information to allow the |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.. . |
| 出版日期 | Book 2016 |
| 关键词 | Pactamycin; Paspaline; Desymmetrization; Natural Product Synthesis; Pactamycin Analogs |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-39025-3 |
| isbn_softcover | 978-3-319-81797-2 |
| isbn_ebook | 978-3-319-39025-3Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing Switzerland 2016 |
发表于 2025-3-21 17:37:12
