Titlebook: Stem Cells in Modeling Human Genetic Diseases; Mayana Zatz,Oswaldo Keith Okamoto Book 2015 Springer International Publishing Switzerland 2

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Modeling Fragile X Syndrome in Human Pluripotent Cells,n 8,000 girls worldwide. A tri-nucleotide CGG expansion at the 5′ untranslated region of the fragile X mental retardation 1 (.) gene leads to CpG methylation of the region and is accompanied by epigenetic changes, resulting in the silencing of the gene. The product of the . gene is the fragile X men

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Induced Pluripotent Stem Cells and Amyotrophic Lateral Sclerosis,c research and the use of different animal models in preclinical studies, most of the evaluated compounds and therapies tested in the last 30 years could not be translated to humans. The advent of induced pluripotent stem cells (iPSCs) technology allowed the generation of models that are more simila

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iPS Cells and Cardiomyopathies,ws the generation of human cardiac platforms in vitro that can be used for modeling a disease of interest, for testing and discovering novel therapeutics. Furthermore, the possibility of generating genetically matched human cardiac progenitor cells and cardiomyocytes (CMs) have much potential in reg

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Cancer Stem Cells and Chemoresistance,ial to mesenchymal transition, B-cell–specific Moloney murine leukemia virus integration site 1, and cell surface markers such as CD44 and CD133. Subsequently, we describe the strategies targeting Hedgehog, Notch, or Wnt/β-catenin pathways. Finally, we add a recent cancer model using induced pluripotent stem cells.

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coupling capacitors.Details effects of inductance on impedan.This book describes methods for distributing power in high speed, high complexity integrated circuits with power levels exceeding many tens of watts and power supplies below a volt. It provides a broad and cohesive treatment of power distr