Titlebook: Stem Cells and Their Potential for Clinical Application; Nadja M. Bilko,Boris Fehse,Axel R. Zander Conference proceedings 2008 Springer Sc

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Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducroma-cell interactions can be supported by locally expressed membranespanning cell-surface growth factors. Ligands of the tyrosine receptor kinases subclass III like SCF or CSF-1 are expressed by stroma as soluble glycoproteins, proteoglycans or membrane-bound glycoproteins. SCF synergizes with othe

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Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cell (HSC) Compartments with limited proliferative potential to multipotent stem cells with extensive proliferative, differentiative and self-renewal capacities. Over a lifetime, the human body produces a trillion blood cells per day. To sustain that enormous cell output, functionally mature cells are generated from high

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Regulation of Hematopoiesis by Growth Factorst defined the hematopoietic stem cell and led to the development of . assays for HGFs. The nature of HGF synergism and the underlying mechanisms, as well as the “permissive” versus “instructive” models of HGF action, are also discussed. In addition, work on one of the HGFs, colony stimulating factor

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Osteopetrotic Models for Identifying Genes that Control Bone Resorptionhin bones. In order for this organ to develop, first bones have to develop that occurs in bony fish and then cellular mechanism of creating the space inside them. This cellular mechanism is dependent on a single new type of cell called the osteoclast that is resorbing bone. Identification of genes w

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Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Lifeessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also docume

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