Titlebook: Stem Cells and Cancer Stem Cells, Volume 8; Therapeutic Applicat M.A. Hayat Book 2012 Springer Science+Business Media Dordrecht 2012 Reprog

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Retention of Stem Cell Properties Post-expansion in Myosphere Culturells (SCs), as the primary source of this capability, originate in the embryonic dermamyotome and are located between the muscular basal membrane and the sarcolemma of mature adult skeletal muscle and compose the tissue-specific stem cell population. In response to muscle damage, SCs proliferation is

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The Role of Bone Marrow-Derived Progenitor Cells in Tumor Growth and Angiogenesis vessels (angiogenesis) or co-opt preexisting ones. Tumor blood vessels are dysfunctional and characterized by excessive branching and sprouting, leakiness, and inflammation. These abnormalities can contribute to tumor progression. For example, in a process resembling healing wounds, tumor cells and

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Myelodysplastic Stem Cells: Gene Expression Profilingranged hematopoietic stem cell (HSC) and a deregulated bone marrow microenvironment. Several abnormalities have been described in the development of myelodysplastic stem cells which give origin to dysplastic hematopoiesis, including increased apoptosis, decreased survival, depletion of early hematop

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Human Mesenchymal Stem Cell Transdifferentiation to Neural Cells: Role of Tumor Necrosis Factor Alphle and can be rapidly expanded .. Additionally, MSCs possess the useful characteristics of stem cell plasticity or transdifferentiation, cytokine/chemokine secretion, and tumor tropism. After . administration, MSCs induce peripheral tolerance and migrate to sites of injury where they promote tissue

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Role of Mesenchymal Stem Cells (MSC) in HIV-1 Associated Bone and Lipid Toxicitiesh the advent of long term anti-retroviral therapy specific toxicities of both bone and lipid tissues have emerged. These issues are of significant clinical importance in a population receiving life-time therapy. The mechanisms underpinning these toxicities have yet to be fully understood, and the re

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Mesenchymal Stem Cell Therapy: Immunomodulation and Homing Mechanismslighted two important aspects of MSC therapy: (1) MSCs can modulate T-cell mediated immunological responses, and (2) systemically administered MSCs home to sites of ischemia or injury. In this chapter, we describe the known mechanisms of immunomodulation and homing of MSCs. First, we examine their n

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Mesenchymal Stem Cells: The Role of Endothelial Cells and the Vasculature are able to differentiate into skeletal lineages, such as bone, cartilage and fat, and as such represent valuable research tools for unravelling the complex mechanisms that control fate determination and developmental processes. Their intrinsic tissue-forming capacity has also elevated MSCs to the