Titlebook: Stem Cells and Cancer Stem Cells, Volume 10; Therapeutic Applicat M.A. Hayat Book 2013 Springer Science+Business Media Dordrecht 2013 Induc

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Differences Between Adipose Tissue-Derived Mesenchymal Stem Cells and Bone Marrow-Derived Mesenchymaentiate in a number of cell lineages. Moreover MSCs are potent regulators of the immune response and they are regarded as new and promising means for therapy of autoimmune diseases, graft versus host diseases etc. MSCs have been isolated by different tissues. The most studied are bone marrow derived

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Transforming Growth Factor-Beta Induced Chrondrogenic Differentiation of Bone Marrow-Derived Mesench chondrocytes, members of the TGF-β superfamily play a decisive role. These factors control not only lineage determination but also the subsequent steps of chondrocyte differentiation. The intracellular signaling molecules of this family, the Smads, are indispensable to regulate, in concerted action

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Drug Discovery Using Human iPSC Based Disease Models and Functional Hepatic Cellsreating a variety of diseases. During the past few years, iPSC generation and hepatic differentiation methods have been significantly improved. These will provide an unlimited source of functional hepatocytes not only for transplantation, but for efficient drug discovery via patient relevant modelin

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Genetic Identification of Human Embryonic Stem Cell-Derived Neural Cell Types Using Bacterial Artifit surprisingly, they have received enormous attention in the context of regenerative medicine. However, harnessing their tremendous potential requires a thorough understanding of their biology and the mechanisms that govern their pluripotency. Directed . differentiation of human embryonic stem cells

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Moderate Low Temperature Preserves the Stemness of Neural Stem Cells (Methods)rlying the amelioration of brain injury by moderate therapeutic hypothermia have not been established. It is considered that neural stem cells reside in the subventricular zone (SVZ) and subgranular zone (SGZ) of the adult mammalian brain and act to regenerate damaged brain tissues. We investigated

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High-Dose Chemotherapy with Autologous Stem Cell Support in the Treatment of Transformed B-Cell Non-re follicular lymphomas and diffuse large B-cell lymphomas, both originating from lymphoid germinal centers. While follicular lymphomas most often have an indolent clinical course, diffuse large B-cell lymphomas are more aggressive and require immediate therapy. Follicular lymphomas and other indole

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The Wnt/β-Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cells with the development of cancer stem cells (CSCs). Elevation of β-catenin activity is critical for blast transformation and drug resistant property of the stem cells in both chronic and acute myeloid leukemia, although the underlying mechanisms are still largely unknown. In this chapter, we will foc

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Bone Marrow Stem Cell Therapies for Diabetes Mellitus and Its Complicationsnts. However, these therapies fail to maintain blood glucose levels in the normal range all the time. Pancreas or islet-cell transplantation achieves better glucose control and substantially improves the quality of life. In this chapter, we summarize stem cell therapies for type 1 and type 2 DM and

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Book 2013tanding of the causes, diagnosis, and therapy of major human diseases and debilitating tissue and organ injuries, using cell-based treatment. This volume presents contemporary research into generation, preservation, and uses of stem cells in fighting disease and tissue/organ injuries..The contents o