Titlebook: Stem Cell Mobilization; Methods and Protocol Mikhail G. Kolonin,Paul J. Simmons Book 2012 Springer Science+Business Media, LLC 2012 bone ma

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Mobilization of Hematopoietic Stem/Progenitor Cells: General Principles and Molecular Mechanisms,res simultaneous expansion of the stem/progenitor cell pool and niche modification. Many of the mechanisms involved in G-CSF-induced mobilization have been described. With regard to mobilization of hematopoietic stem/progenitor cells, challenges for the future include the analysis of genetic factors

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Quantifying Hematopoietic Stem and Progenitor Cell Mobilization,d as a major source of hematopoietic stem and progenitor cells (HSPC) for transplantation protocols. It is, therefore, essential to evaluate and to quantify the extent by which the HSPC are mobilized and enriched in the circulation in correlation with their long-term hematopoietic reconstitution cap

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Hematopoietic Stem Cell Mobilization with G-CSF,ced bone marrow as the stem cell source. In recent years, a dramatic increase has been reported in the use of peripheral blood stem cells for allogeneic transplantation as well. The reason for this rise is that peripheral blood stem cell transplants when compared to bone marrow transplants are assoc

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Hematopoietic Stem Cell Mobilization with Agents Other than G-CSF, from the peripheral blood of patients or donors treated with granulocyte-colony stimulating factor (G-CSF) are the preferred source for transplantation. G-CSF mobilization regimens, however, are associated with known morbidities and a significant number of normal donors and patient populations fail

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Hematopoietic Progenitor Cell Collection,yeloid cytokines (GCSF, GMCSF, IL3), a CXCR4 antagonist (Plerixafor) and/or following a hematopoietic recovery from cytotoxic chemotherapy. The hematopoietic stem and progenitor cells are contained within the mononuclear cell fraction of peripheral blood and can be collected by apheresis in which th

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