书目名称 | Stearoyl-CoA Desaturase Genes in Lipid Metabolism | 编辑 | James M. Ntambi, Ph.D. | 视频video | | 概述 | First book to focus on SCD Genes in Lipid Metabolism.This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver, metabolism, Colitis, and more?.Gives an overvie | 图书封面 |  | 描述 | Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse | 出版日期 | Book 2013 | 关键词 | Endocrinology; Gene Regulation; Lipids; Metabolism; SCD Genes | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4614-7969-7 | isbn_softcover | 978-1-4939-0153-1 | isbn_ebook | 978-1-4614-7969-7 | copyright | Springer Science+Business Media New York 2013 |
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