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Titlebook: Statistical Analysis of Proteomic Data; Methods and Tools Thomas Burger Book 2023 The Editor(s) (if applicable) and The Author(s), under ex

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Robust Prediction and Protein Selection with Adaptive PENSE,alues without causing severe detrimental effects to the estimated predictive model. The method is implemented as an R package and supports the user in the model selection process by automating most steps and providing diagnostic visualizations to guide the user. Users can choose among several predic
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Towards a More Accurate Differential Analysis of Multiple Imputed Proteomics Data with mi4limma,ers and their variability, thanks to Rubin’s rules. The imputation-based peptide’s intensities’ variance estimator is then moderated using Bayesian hierarchical models. This estimator is finally included in moderated .-test statistics to provide differential analyses results.
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Multivariate Analysis with the R Package mixOmics,amples into known groups. We then present integrative methods with Projection to Latent Structures and further extensions for discriminant analysis. We illustrate each technique on a breast cancer multi-omics study and provide the R code and data as online supplementary material for readers interested in reproducing these analyses.
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Integrating Multiple Quantitative Proteomic Analyses Using MetaMSD, repositories to discover new biomarkers and generate interesting hypotheses for future studies. In this protocol, we provide a step-by-step procedure on how to install and perform a meta-analysis for quantitative proteomics using MetaMSD.
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Book 2023are both user-friendly and state-of-the-art in chemo- and biostatistics. Beginning with methods to control the false discovery rate (FDR), the volume continues with chapters devoted to software suites for constructing quantitation data tables, missing value related issues, differential analysis soft
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Fast, Free, and Flexible Peptide and Protein Quantification with FlashLFQ, methods and can quantify data-dependent analysis (DDA) search results from any proteomics search program. It is available as a graphical user interface program, a command line tool, a Docker image, and integrated into the MetaMorpheus search software.
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