Titlebook: Special Topics in Carcinogenesis; Symposium of the “Ge E. Grundmann Book 1973 Springer-Verlag Berlin · Heidelberg 1973 cancer.carcinogenesi

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Enzyme Histochemistry of Human TumorsThe value of histochemical enzyme reactions in the study of human tumors for clinical-pathological purposes has been extensively investigated in many laboratories. Such studies have also been made in our department during the past 18 years (W. 1956, 1959, 1960, 1961 a, b, 1963; W.. 1959, 1963, 1968; P.. 1960, 1965; T.. 1966, 1967 a, b, 1969).

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The Histology of Rare Human Tumors and their Relationships to General Tumor PathologyCertain human tumors may be considered rare in the light of certain facts:

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Early Changes in Ploidy and Cytogenetics of Liver Cells After Diethylnitrosamine TreatmentChanges in function and growth in the liver cell can be produced by relatively simple experimental mechanisms. All types of growth-changes, embryonic, regenerative and malignant are easy to induce.

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Experimental Intestinal Carcinogenesis and Polyp Development in Rats and Mice1, 2-dimethylhydrazine (DMH), the carcinogen used in this experiment is characterized by marked organotropy and certainty of tumor production in the small and large intestine of rats (D.., 1967). It is also active in mice (W.., 1969).

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978-3-642-80788-6Springer-Verlag Berlin · Heidelberg 1973

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Special Topics in Carcinogenesis978-3-642-80786-2Series ISSN 0080-0015 Series E-ISSN 2197-6767

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Formation of Carcinogens From Precursors Occurring in the Environment: New Aspects of Nitrosamine — . g. polycyclic aromatic hydrocarbons such as 3,4-benzypyrene, released during combustion) and such “naturally occurring” substances as aflatoxin, a metabolite of a mold fungus, and various carcinogens of plant origin.

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The Replication of RNA Tumor Viruseshis tool is provided by nature itself; cancer is induced upon infection by certain viruses. There are DNA and RNA-containing viruses which can transform normal cells into malignant cells as Dr. P. pointed out.