Titlebook: Space, Time and the Limits of Human Understanding; Shyam Wuppuluri,Giancarlo Ghirardi Book 2017 Springer International Publishing AG 2017

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Nicholas Maxwell, such as, penetrability of the blood-brain barrier. By their nature, psychoactive drugs fulfill this important pharmacologic feature. Our preliminary studies of the effects of opioids, benzodiazepines, thalidomide, and St. John’s wort on microglia suggest that drugs which target the brain’s immune

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Gerard ’t Hooftutoimmunity targeting brain proteins is enigmatic, because traditionally, the central nervous system (CNS) is viewed as immune-privileged. However, the discovery of the lymphatic and glymphatic circulation in the CNS demonstrates the interaction between the CNS and the immune response. Furthermore,

Brain-Waves

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Norbert Straumannss, heat, swelling, loss of function, and pain. Because of its relationship with pain and injury, various treatments for inflammation have been historically documented. During inflammation, pro-inflammatory mediators can be produced by infiltrating and resident immune cells. These pro-inflammatory m

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C. S. Unnikrishnan cell therapy.Offers an introduction to acute and chronic paAs lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited.  Anti-inflammatory drugs can only do so much, while painkillers like opioids h

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Joan A. Vaccaroe of brain cells and their connections. Linked to aging, epidemiologic, animal, human, and therapeutic studies all support the presence of a neuroinflammatory cascade in disease. This is highlighted by the neurotoxic potential of microglia. In steady state, microglia serve to protect the nervous sys

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George Musserts are now available, MS represents a major target for research into the development of disease-modifying therapies that specifically focus on the neuroimmune pathways of myelin and tissue damage that currently are incompletely understood. Multiple sclerosis is considered to be an example of develop