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Titlebook: Somatostatin; Basic and Clinical S Seymour Reichlin (Chairman) Book 1987 Springer Science+Business Media New York 1987 Insulin Secretion.Pa

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Somatostatin Receptor: Evidence for Functional and Structural HeterogeneitySomatostatin, like many other peptide systems, is a multigene family with two principal bioactive forms corresponding to somatostatin-14 (S-14) and somatostatin-28 (S-28) (1).
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Structural Analysis of Somatostatin ReceptorsSomatostatin receptors have been characterized by ligand binding studies using intact cells or cell lines and membrane fractions from various tissues including brain (1,2), anterior pituitary (3–5), adrenal cortex (6,7), and both exocrine (8–10) and endocrine (11) pancreas.
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Mode of Action of Somatostatin in Islet B-Cells: Influence on Glucose-, L-Isoleucine- and Glyburide-The widespread role of somatostatin (SRIF, somatotropin release inhibiting factor) as a modulator of neural activity as well as endocrine and exocrine secretion has stimulated interest in its mechanism of action.
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Mechanisms by which Somatostatin Inhibits Pituitary Hormone ReleaseSince somatostatin inhibits secretion in a wide variety of target cells, studies probing its mechanism of action have focused on the involvement of the two intracellular messengers known to regulate secretory processes: cyclic AMP and calcium (see reviews 1–5).
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https://doi.org/10.1007/978-1-4684-5326-3Insulin Secretion; Pancreas; biosynthesis; brain; diabetes; growth; homeostasis; hormone; insulin; molecule; n
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