Titlebook: Soft Tissue Pathology for Clinicians; Kyle Perry Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spr

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Grading, Staging, and Reporting of Soft Tissue Tumors,uch as tumor grade and stage. In the realm of soft tissue pathology, differentiation of the tumor, mitosis and necrosis are utilized to assign grade. The extent and size of tumor are employed to assign pathologic stage. Familiarity with these elements and the structure of a surgical pathology report

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Lipomatous Tumors,at contain cytoplasmic lipids which are responsible for their clear appearance under the microscope (Fig. 4.1). Lipoblasts contain one or more smaller clear cytoplasmic vacuoles that indent or displace the nuclei (Fig. 4.2). Some lipomatous tumors (e.g., lipoma) frequently occur, while others (e.g.,

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Fibroblastic/Myofibroblastic Tumors,r ligaments. Fibroblasts appear as spindle cells with elongated nuclei and variable amounts of associated eosinophilic collagen deposition (Fig. 5.1). Myofibroblasts can be spindled or star-shaped and demonstrate some muscle-type antigens (e.g. smooth muscle actin) by immunohistochemistry. The behav

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Fibrohistiocytic Lesions, and macrophages. The fibroblastic-appearing cells typically have elongated and spindled nuclei and are arranged in a streaming pattern (Fig. 6.1a). Cells with a more histiocytic appearance are less organized and have a “foamy” cytoplasm (Fig. 6.1b) [1].

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Smooth Muscle and Perivascular Tumors, tumors can also be found in almost any anatomic location. Morphologically, the neoplastic cells of smooth muscle tumors are noted to have eosinophilic cytoplasm and elongated or ovoid nuclei (Fig. 7.1a)..Perivascular tumors contain a modified type of myoid cell that is associated with the vascular

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Skeletal Muscle Tumors,ing arrangement of thin and thick myofilaments (Fig. 8. 1). These cells can be seen in varying degrees in soft tissue tumors with skeletal muscle differentiation. However, in tumors that are poorly differentiated, rhabdomyoblastic differentiation must sometimes be confirmed by immunohistochemical st

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Neural and Nerve Sheath Lesions,further organized into bundles that are supported and surrounded by connective tissue and covered by perineurium. In neural and nerve sheath neoplasms, one or a combination of these anatomic structures proliferate to form a soft tissue mass.

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