Titlebook: Sleep, Benzodiazepines and Performance; Experimental Methodo Ian Hindmarch,Helmut Ott,Tom Roth Conference proceedings 1984 Springer-Verlag

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Hypnotic Drugs for 1984llowed by withdrawal phenomena, including complaints of insomnia and anxiety. The long-acting, cumulative drugs like phenobarbitone or flurazepam cannot in reality be withdrawn abruptly owing to their persistence in the tissues, and so they do not cause sharp rebound phenomena, though they cause imp

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Pharmacodynamics of Benzodiazepines After Single Oral Doses: Kinetic and Physiochemical Correlatesbarrier permeability. When given parenterally all benzodiazepines rapidly enter brain tissue and have a rapid onset of action, indicating that passage from blood to brain is not the rate-limiting factor (Arendt et al. 1983). Rather it is the difference in rate of absorption — passage from the gastro

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Modern Trends in the Investigation of New Hypnotics in AnaesthesiaSleep has been studied with the help of EEG measures and side-effects have been evaluated by psychometric tests. The EEG is a proven parameter with regard to dosage determination and as objective means to find sleep-inducing quantities of drugs. By means of vigilosomnograms we have established dose-

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Are Electroencephalographic and Psychomotor Measures Sensitive in Detecting Residual Sequelae of Bencting (LBD) and short-acting (SBD) benzodiazepines, when used as nighttime sedatives. The question now arises as to which electrophysiological and psychometric tests can record these effects with the highest degree of sensitivity... 35 healthy volunteers participated in 3 randomized double-blind pla

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Are the Amplitudes of Visual Evoked Potentials Sensitive Indices of Hangover Effects After Repeated iazepines. Twelve hours after the last ingestion, possible effects on evoked potentials (EPs) of the long- and short-acting benzodiazepines, flurazepam and lormetazepam, were compared here with those of placebo under a double-blind experimental condition. The EPs were recorded from occipital and par

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The Effects of Benzodiazepines on Short-Term Memory and Information Processing task were investigated in ten normal volunteers..Overall reaction times for the task were increased 1 h following treatment with triazolam and both 1 h and 10 h following treatment with flunitrazepam. Response latencies were not appreciably altered by lormetazepam or placebo..The effects of flunitr

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Conference proceedings 1984 per­ formance during the VII. International Congress of Psychiatry in Vienna 1983. Authors were asked to examine and review the methods used and the results obtained from the various studies within their particular expertise and to provide guidelines for future strategies in the psychopharmacology