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Titlebook: Sjögren‘s Syndrome and Oral Health; Disease Characterist Seunghee Cha Book 2021 Springer Nature Switzerland AG 2021 Sjögren‘s syndrome in d

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Innate Immune Dysregulation in Sjögren’s Syndromey. While adaptive immunity is clearly dysregulated in pSS, the innate immune response also mediates disease pathogenesis in both pSS mouse models and patients. Moreover, studies in mice suggest that activation of innate immunity precedes the adaptive. Many different cell types that contribute to inn
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B Cell Expansion and Neoplasia in Sjögren’s Syndromell hyperactivity leading to the production of autoantibodies, such as anti-Ro (SS-A), La (SS-B), and rheumatoid factor (RF), and a 40-fold increased risk of extranodal B cell lymphoma arising in the inflamed salivary glands, especially the parotid glands. Although most of the cells infiltrating the
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Recurrent Vs. Persistent Salivary Gland Swelling in Differential Diagnosis of Sjögren’s Syndromerimary SS and secondary SS. Primary SS occurs in 50% of cases and affects only the salivary and lacrimal glands leading to dry eyes and dry mouth. Secondary SS is characterized by presence of a secondary autoimmune disease such as rheumatoid arthritis, scleroderma, or lupus along with lacrimal and s
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Pharmacological Management of Sjögren’s Syndromeal groups have suggested various recommendations for SS treatments that can be translated to clinical practice. To relieve sicca manifestations, muscarinic agonists, such as pilocarpine and cevimeline, are widely used as oral secretagogues, in addition to topical therapies. Several hyposalivation-re
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Clinical Management of Dry Eye in Sjögren’s Syndrome adversely affecting patients’ quality of life. Proper ocular evaluation is mandatory for the diagnosis of Sjögren’s syndrome and for the exclusion of other ocular conditions. Although management of dry eye in Sjögren’s syndrome is not quite different from non-Sjögren’s syndrome dry eye, severe aque
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