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Titlebook: Sinus node inhibitors; A new concept in ang Å. Hjalmarson (Professor of Cardiology),W. J. Remm Conference proceedings 1991 Dr. Dietrich Ste

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Conference proceedings 1991e, in the majority of patients treatment will be conservative for a number of reasons, the cost-effectiveness of non-pharmacological approaches being of major importance. During the last two decades, drug development for ischemic heart disease has been impressive and many new compounds have been add
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Antiischemic, antianginal, and hemodynamic effects of ULFS 49 CL (a new heart-rate-reducing agent) compound’s underlying mechanism of action to decrease heart rate can be explained by an inhibition of the i.-current, which seems to be responsible for the spontaneous depolarization of the pacemaker cells in the sino-atrial node [1, 2]. Like β-blockers, the substance is expected to produce a reduct
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978-3-7985-0861-3Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1991
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Efficacy and duration of action of three doses of Zatebradine (ULFS 49 CL) in patients with chronicZatebradine (ULFS 49 CL) is a member of a new class of drugs, the so-called sinus node inhibitors that specifically reduce the spontaneous rate of depolarization of the pacemaker cells in the sino-atrial node [5, 6], leading to a decrease in heart rate.
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