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Titlebook: Single Subject Designs in Biomedicine; Janine E. Janosky,Shelley L. Leininger,Terry M. Li Book 2009 Springer Science+Business Media B.V. 2

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Methodological Framework for Single Subject Designs,igns have comparable or stronger internal validity but are more limited in some aspects of external validity; that is, the single subject design may provide more definitive conclusions, but it can be more difficult to generalize those conclusions to other participants or patients. Strategies for overcoming these limitations are examined.
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Annotated Bibliography of Single Subject Studies,es DI. Development and in vitro testing of a new method of urine preparation for retrograde ejaculation: The Liverpool solution. .. 2008; 89(4): 885–891. The investigators tested the effectiveness of a new method for oral preparation of urine for sperm retrieval after retrograde ejaculation. MEDLINE
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Book 2009 extends the application to the field of biomedicine. Biomedical illustrations are used to demonstrate the processes of designing, implementing, and evaluating a single subject design. Strengths and limitations of various methodologies are presented, along with specific clinical areas of application
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Overview of the Single Subject Design,is design, however, has recently been applied for investigations in medicine that have involved a multitude of clinical and biomedical areas such as drug therapy [3], gastroenterology [4, 5], internal medicine [5], pediatrics [6], family medicine [7, 8], cardiology [9], and nutrition [10], among others [3, 6, 11–13, 14–31].
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Ethics and Single Subject Research, the foundation of proficient decision making. Then, ethical issues involving patients’ rights and methodological considerations are reviewed. In closing, single subject design research is described as playing a key role in ethical biomedical research.
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