| 书目名称 | Single Nucleotide Polymorphisms | | 副标题 | Human Variation and | | 编辑 | Zuben E. Sauna,Chava Kimchi-Sarfaty | | 视频video | | | 概述 | Features multiple case studies that illustrate the SNP analysis process.Provides a guide with illustrative examples to using databases of SNPs their role in human variation.Offers a unique broad surve | | 图书封面 |  | | 描述 | .This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of evolutionary forces that have generated SNPs. It also has shown how SNPs shape human variation. The ability to inexpensively generate and analyze vast amounts of genetic data is poised to transform our understanding of human evolution and biology. “Single Nucleotide Polymorphisms” covers a broad survey of SNPs and their classification into synonymous and non-synonymous; the role of SNPs in human disease; case studies providing specific examples of synonymous and non-synonymous SNPs associated with human diseases or affecting therapeutic interventions; mechanisms by which synonymous mutations affect protein levels or protein folding which affect human physiology and response to therapy; and the role of SNPs in personalized medicine. Understanding what SNPs are, how they have been shaped i | | 出版日期 | Book 2022 | | 关键词 | DNA; GWAS; Genome; SNPs; genotyping; transcription | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-031-05616-1 | | isbn_ebook | 978-3-031-05616-1 | | copyright | Springer Nature Switzerland AG 2022 |
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发表于 2025-3-21 17:54:20
