Titlebook: Signalling from Internalised Growth Factor Receptors; Inger Helene Madshus Book 2004 The Editor(s) (if applicable) and The Author(s), unde

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Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/s/image/867187.jpg

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细菌等

Met Receptor Dynamics and Signalling,tor downregulation, and a mutant receptor defective in Cbl binding is able to transform cells. We discuss the hypothesis that some naturally occurring Met mutants implicated in cancer may transform cells owing to defects in their trafficking along the endosomal degradation pathway.

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0070-217X wledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with ho

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neuron

Met Receptor Dynamics and Signalling,ogenetic processes. This process is important for development and organ regeneration, but dysregulation in transformed tissues can contribute to cancer progression and metastasis. Acute stimulation of tissue culture cells with HGF leads to Met downregulation via degradation through an endocytic mech

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Signaling, Internalization, and Intracellular Activity of Fibroblast Growth Factor,icated in regulation of many key cellular responses involved in developmental and physiological processes. These includes proliferation, differentiation, migration, apoptosis, angiogenesis, and wound healing. FGFs bind to five related, specific cell surface receptors (FGFRs). Four of these have intr

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Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction,itiated by its ligand. Like many growth factor receptors, specific molecular mechanisms guarantee that a receptor can signal only once in its lifetime. Three features render the GH receptor unique: (a) an active ubiquitination system is required for both uptake (endocytosis ) and degradation in the