Titlebook: Sigma Proteins: Evolution of the Concept of Sigma Receptors; Felix J. Kim,Gavril W. Pasternak Book 2017 Springer International Publishing

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Dedication

Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/s/image/867036.jpg

警告

https://doi.org/10.1007/978-3-319-65853-7Chaperone; Neurodegenerative disease; Pain; Pathophysiology; Protein homeostasis; Scaffold

使闭塞

Felix J. Kim,Gavril W. PasternakProvides an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology.Emphasis is laid on the roles of sigma pro

Interdict

978-3-319-88116-4Springer International Publishing AG, part of Springer Nature 2017

共和国

Sigma Proteins: Evolution of the Concept of Sigma Receptors978-3-319-65853-7Series ISSN 0171-2004 Series E-ISSN 1865-0325

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,Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases,athogenesis. Here, we will review genetic and pharmacological evidence of σ. receptor engagement in learning and memory disorders, cognitive impairment, and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease.

娘娘腔

Sigma-1 Receptor and Neuronal Excitability, will describe and discuss the latest findings on Sig-1R-dependent modulation of VGICs and LGICs, and provide hypotheses that may explain the diverse excitability outcomes that have been reported so far.

PET-scan

Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors,ors can physically associate with GPCRs. Together, these findings show that sigma. ligands can function as allosteric modulators of GPCR function through their association with the sigma. receptors, which are in direct physical association with opioid receptors, members of the G-protein coupled family of receptors.

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