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Titlebook: Side-Effects of Anti-Inflammatory Drugs 3; K. D. Rainsford,G. P. Velo Book 1992 Springer Science+Business Media Dordrecht 1992 kidney.live

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Book 1992 Drugs" which was held under the auspices of the University of Verona, Institute of Pharmacology in Verona on 8-11 May 1991. This meeting was held in conjunction with the 13th European Workshop on Inflammation and although publications from this part of the meeting are not published here (they appea
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Novel strategies of gastric and duodenal mucosal protection against NSAID injury: role of protease iilarities and differences with non-specific ‘peptic’ ulcers, e.g. the natural history of both lesions is incompletely understood and while NSAID gastropathy is more frequent in females and localized mostly in the stomach, ‘peptic’ ulcers are more prevalent in males and in the duodenum [2].
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The gastrointestinal toxicity of the non-steroidal anti-inflammatory drugs44 million patients in 1984 [1]. The utility of these drugs is, in part, due to the high frequency of gastric intolerance to aspirin. Unfortunately, gastrointestinal (GI) side-effects are also the most frequent adverse reactions to NSAIDs [2]. The GI problems reported vary from mild symptoms, such a
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The value of the case—control approach for the evaluation of the risk of upper gastrointestinal bleeor non-steroidal anti-inflammatory drugs (NSAIDs) as a whole [12–14]. However, specific estimates for individual drugs are not available because the lower prevalence of use of each individual NSAID — compared with that of ASA — limits the statistical power of any analytical study designed to quantif
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What can a spontaneous reporting system teach about side-effects of anti-inflammatory drugs?lthough the requirements for demonstrating efficacy and safety vary from country to country, they can usually be satisfied by including from a few hundred to 3000 patients in pre-approval testing. In countries without the requisite infrastructure, drugs may be licensed without local testing, accepti
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