Titlebook: Side-Effects of Anti-Inflammatory Drugs; Part One Clinical an K. D. Rainsford,G. P. Velo Book 1987 MTP Press Limited 1987 Arthritis.drug.in

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Non-steroidal anti-inflammatories: outpatient audit of patient preferences and side-effects in diffeatistically different from one another)? Does it matter which drug is chosen for a specific disease? To answer these questions we have asked patients attending routine rheumatology outpatient clinics to try quartets of NSAIDs. So far 1200 patients have been recruited into eight quartets.

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Drug interactions between the anti-inflammatory drugs and with other agents drugs that are in common use. The antiinflammatory analgesic drugs are no exception to such occurrence. This is not unexpected because of the wide use of these drugs in the community. For example, latest figures available in Great Britain. show that some 19 million prescriptions for antiinflammator

GROG

Interaction between non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitoosterone, and increasing the production of kinins (angiotensin-converting enzyme is also a kininase II) (Figure 1). This leads to a decreased vasoconstriction of the kinin and to a potentiation vasodepressor system with vasodilatory and antihypertensive effectsl. A rise in kinin levels stimulates an

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Responders and non-responders to NSAI drug interactions — a neglected problem?of anti-hypertensive and diuretic agents.. The clinical relevance and therapeutic implications of these findings are not clear at the present time due to the fact that there are large discrepancies between the findings themselves and their interpretation by the respective authors. There is, particul

FIN

Biological implications of the metabolic chiral inversion of 2-arylpropionic acid non-steroidal antiidely used. Currently, the 2-arylproprionic acids, or “profen” NSAIDs are an important sub-group of this class of drug. Over recent years there has been an increasing interest in the problems of adverse reactions to therapeutic agents of all types, in terms both of their prediction and prevention, a

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Rare adverse reactions to non-steroidal anti-inflammatory drugsrous reactions suggest society does not have methods for adequately assessing the safety of new drugs. Sulindac (Clinoril) is of special interest, since it causes two rare but unusual reactions — agranulomatous hepatitis and acute pancreatitis — and also since it possibly may have less renal toxicity than other NSAIDs.

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Pyrazoione-induced agranulocytosis: an epidemiological evaluationnge is ethically unaccep-table.Such ad hoc judgments are often biased in implicating drugs already under suspicion.In addition the inaccurate documentation of the temporal relationship between drug exposure and the event give rise to serious problems of misclassification.