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Titlebook: Sickle Cell Disease and Hematopoietic Stem Cell Transplantation; Emily Riehm Meier,Allistair Abraham,Ross M. Fasano Book 2018 Springer Int

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Neurological Manifestations of Sickle Cell Disease and Their Impact on Allogeneic Hematopoietic Stemith SCA and the impact of pre-existing neurological conditions on HSCT complications and outcomes. We identify knowledge gaps and highlight recent developments. We also suggest a standardized clinical approach for assessing neurological complications of SCA before, during, and after HSCT.
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Overview of Hematopoietic Stem Cell Transplantation for Nonmalignant Diseaseslism, and aplastic anemia and bone marrow failure syndromes. Furthermore, it touches on recent developments in reduced intensity conditioning regimens, GVHD prophylaxis, and the management of post-transplant infection risks.
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Haploidentical Hematopoietic Cell Transplantation for Sickle Cell Diseaseransplant conditioning regimen have led to promising results from ongoing clinical trials. Ultimately, innovative approaches such as cell therapies may be needed to make haploidentical transplantation a safe and effective curative option for sickle cell disease.
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Current Non-HSCT Treatments for SCDth care and public policies have successfully reduced the mortality in children with SCD and has led to its evolution into a chronic disease in adults living with SCD. While management of SCD remains largely symptomatic with only one FDA-approved pharmacologic disease-modifying agent hydroxyurea, im
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