Titlebook: Shock, Sepsis, and Organ Failure; Second Wiggers Berna Günther Schlag,Heinz Redl,Daniel L. Traber Conference proceedings 1991 Springer-Verl

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Hypoxic Damage of the Gut in Shock hemorrhagic, superficial mucosal injury found in the small intestine following even shortperiods of hypotension or ischemia. Microscopically detectable mucosal injury is found after 20 min of total warm intestinal ischemia (Park et al 1990). A series of observations indicate that damage to the vill

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Experimental Evidence of Bacterial Translocation in Traumanctions, the intestine must also serve as a major defense barrier to prevent bacteria colonizing the gut from invading systemic organs and tissues. Based on epidemiologic studies, the mucosal barrier to bacteria appears to be lost under certain clinical circumstances resulting in systemic sepsis (1,

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Bacterial Translocation in a Baboon Model of Hypovolemic-Traumatic Shockltiorgan failure patients with clinical manifestations of sepsis had an identifiable focus of infection (Goris 1985). The majority of ICU patients demonstrate the picture of clinical sepsis without a focus. In these patients, the gut frequently plays an important part as a shock organ involved in th

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Bacterial Translocation Across a Histologically Intact Intestinal Mucosaon of the complicating infections seen in hospitalized immunosuppressed patients, trauma patients, and postsurgical patients (reviewed in Wells et al. 1988c). If the intestinal tract is damaged as a result of a variety of insults such as local ischemia, it is not difficult to imagine that intestinal

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Clinical Evidence of Bacterial Translocation from the Gutsuspect. Purging, sometimes violently, often combined with bleeding was a common remedy of our medical forebears. Wiggers in his classic on shock in 1950 mentions that bacteria might possibly make their way out of the colon as a result of ischemic damage to tissues.

dendrites

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Increased Glucose Uptake and Superoxide Anion Production after Priming or Activation of Hepatic Phagvarious sinusoidal cells has only been appreciated during the last several years (Brouwer, et al, 1988; Anthony and Summerfield, 1988). It is now known that the nonparenchymal cells of the liver perform a variety of important functions that are interrelated with one another and with the normal funct