Titlebook: Serine Proteases and Their Serpin Inhibitors in the Nervous System; Regulation in Develo Barry W. Festoff (Director),Daniel Hantaï Book 199

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harpsichord

Induction of the Urokinase-Type Plasminogen Activator Gene by Cytoskeleton-Disrupting Agents whose products assist in reshaping the intracellular cytoskeleton and the extracellular matrix. How and whether changes in cell morphology and cytoskeletal components may cause alterations in the expression of certain genes has not yet been investigated extensively.

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Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and These studies have used mainly the techniques of protein chemistry. The last part of the article will consider the use of site-directed mutagenesis to elucidate areas of hirudin important for its inhibitory activity.

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verdict

Regulation and Control of the Fibrinolytic Systemminogen activator inhibitors (PAI-1 and PAI-2), or at the level of plasmin, mainly by α.-antiplasmin. Plasminogen activation may also be induced by an “intrinsic” pathway involving several proteins such as Factor XII, high molecular weight kininogen (HMWK) and prekallikrein.

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Thrombin Structural Regions in Determining Bioregulatory Functions and activated proteins of the blood-coagulation, fibrinolytic, and complement systems, thrombin has multiple bioregulatory functions, which are central in hemostasis, wound healing, and perhaps developmental, as well as certain disease processes..

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Regulation and Control of the Fibrinolytic Systemtive proenzyme, plasminogen, which can be converted to the active enzyme plasmin, that will degrade fibrin into soluble fibrin degradation products. Two immunologically distinct types of physiological plasminogen activators have been identified: the tissue-type plasminogen activator (t-PA) and the u

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ONYM

Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cellss,. serine proteases,. and mediators of inflammation.. Among the cells producing t-PA is the endothelial cell. One of the proposed functions of the vascular endothelium is to maintain or reestablish a homeostatic environment through a variety of pathways, including the production and release of t-PA