Titlebook: Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases; Takuya Hidaka Book 2022 Springer Nature Singapore Pte Ltd. 2022 M

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使纠缠

Introduction,rrent therapeutic approaches. In addition, pyrrole-imidazole polyamides, a class of DNA-binding ligands with sequence programmability, are introduced as promising drug candidates to modulate DNA mutation and abnormal RNA transcription.

得意牛

Lamina

Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-Arginine vector improves biological activity of PIPs and PIP–tri-arginine conjugates achieve efficient transcription inhibition of SOX2-downstream genes in induced pluripotent stem (iPS) cells and . oncogene in human breast cancer cells. This simple vector expands the application of long PIPs by overcoming the compound delivery problems.

Kindle

Constitution

Compassionate

Introduction,ut mitochondria also act as hubs for biosynthesis and metabolic waste management and as balancers to maintain cellular homeostasis. Due to the central role in cells, defects in mitochondrial function cause a critical impact on our body, making mitochondrion an attractive target for therapeutic purpo

pancreas

Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Traelation between mitochondrial genome and diseases. In this chapter, a new type of synthetic DNA-binding ligands, termed MITO-PIPs, was developed by conjugating a mitochondria-penetrating peptide with pyrrole-imidazole polyamides (PIPs). A MITO-PIP that inhibits the binding of mitochondrial transcrip

Laconic

Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation d from cells, no chemical-based drugs in clinical trials have the potential to modulate mtDNA mutation and cure mitochondrial diseases permanently. To achieve selective elimination of mitochondrial DNA with mutant adenine base, I develop a conjugate of MITO-PIP and chlorambucil (Chb), which can alky

肥料

Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-Arginine hes utilizing pyrrole-imidazole polyamides (PIPs) have potential to modulate nuclear DNA transcription and replication based on DNA sequence information, their application in living cells has achieved limited success due to the moderate or poor nuclear accumulation of PIPs. In this chapter, I show t