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Titlebook: Sense and Senility: The Neuropathology of the Aged Human Brain; The Neuropathology o David M. A. Mann Book 1997 Springer Science+Business M

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书目名称Sense and Senility: The Neuropathology of the Aged Human Brain
副标题The Neuropathology o
编辑David M. A. Mann
视频video
图书封面Titlebook: Sense and Senility: The Neuropathology of the Aged Human Brain; The Neuropathology o David M. A. Mann Book 1997 Springer Science+Business M
描述nly two things are certain in life, one is that all of us will inevita­ Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio­ ration in the structural and functional integrity of our bodies, this pro­ gressing to such an extent that one or more organ systems will eventu­ ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the musculo-skeletal, cardiovascular, or endocrine systems producing arthri­ tis, hypertension, stroke or diabetes are all too apparent in our elderly population yet internally caused failures in the function of the nervous system provide the common, and mostly intractable, problems of memory and intellect or locomotion that face and frustrate clinicians. Perhaps the most important factor which can decide the outcome of research studies professing to examine the effects of the passage of time (i. e. the ‘process of aging‘) on the function of the nervous system, or indeed any other organ system, is the selection of appropriate or repre­ sentative subjects for investigation. The heart of this proble
出版日期Book 1997
关键词Alzheimer; Nervous System; Parkinson; aging; alzheimer‘s disease; brain; diabetes; memory; neuropathology; st
版次1
doihttps://doi.org/10.1007/978-1-4615-6001-2
isbn_softcover978-1-4613-7749-8
isbn_ebook978-1-4615-6001-2
copyrightSpringer Science+Business Media Dordrecht 1997
The information of publication is updating

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Introduction,ocess we shall die. Inherent to the passage of time is a deterioration in the structural and functional integrity of our bodies, this progressing to such an extent that one or more organ systems will eventually begin to fail with the continued health and well-being of the individual coming under thr
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Pathological Changes in Neurodegenerative Disease,pathological terms, between the effects of so-called normal aging and those of the common neurodegenerative diseases of later life (i.e. AD, PD). Pathological diagnoses of AD and PD are made on the basis of the amount, rather than the type, and distribution of damage imposed upon the brain. In clini
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Etiological Considerations,rited. In certain instances the disease may be inherited in what appears to be a classical autosomal dominant fashion, though the genetic basis for this has become apparent only during the past decade. Inheritance seems to be strongest in families where disease onset occurs before 65 years of age, t
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Relationships Between Aging and Neurodegenerative Disease,old age (AD and PD) show much overlap. For example, in AD the larger pyramidal cells of the cerebral cortex (especially those of the frontal, temporal and cingulate gyri) and the hippocampus (CA1 and subiculum), amygdala (cortical and medial nuclei), suprachiasmatic nucleus, nucleus basalis complex,
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Etiological Considerations,hough familial disease in later life may be much more common what has formerly seemed to be the case because of potentially affected individuals dying from unrelated causes before reaching the age at risk or during the early and clinically unrecognized stages of the disease.
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