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Titlebook: Selectivity and Molecular Mechanisms of Toxicity; F. Matteis,E. A. Lock Book 1987 The contributors 1987 city.mechanism.research.toxicity

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Toxicology of Impurities in Malathion: Potentiation of Malathion Toxicity and Lung Toxicity Caused bextended the range of toxic organophosphorus structures. It is not surprising therefore that amongst these structures, compounds are found with biological activities other than, and in addition to, those depending on inactivation of acetylcholinesterase. The range of structures and biological reactions are illustrated in figures 11.1 and 11.2.
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Drugs as Suicide Substrates of Cytochrome P-450many potentially toxic chemicals are present in our environment; and also by the appreciation that drug-metabolising reactions are not only important in detoxifying chemicals, but in many cases can actually initiate toxic responses, by converting inert drugs into biologically reactive derivatives. T
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Parkinsonian Syndrome Caused by 1-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Man and Animaes and tremor which he had observed by casual observation of individuals from his window or by chance encounters in the street. Subsequently, Charcot re-named the disease Parkinson’s disease since the limbs were not flaccid or paralysed, as the term palsy implied, but exhibited a marked rigidity. Si
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Hexane Neuropathy: Studies in Experimental Animals and Manational Safety and Health (NIOSH) has estimated that over 2 million workers per year in the US are exposed to significant levels of n-hexane in the course of their workday (NIOSH, 1977). NIOSH has also named more than 40 industrial classifications and processes in which n-hexane is commonly employed
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