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Titlebook: Schwann Cell Development and Pathology; Kazunori Sango,Junji Yamauchi Book 2014 Springer Japan 2014 Axonal degeneration.Coculture systems.

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发表于 2025-3-21 19:05:13 | 显示全部楼层 |阅读模式
书目名称Schwann Cell Development and Pathology
编辑Kazunori Sango,Junji Yamauchi
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概述Presents up-to-date topics utilizing cutting-edge techniques, such as newly developed spontaneously immortalized Schwann cell lines.Provides deep insights into Schwann cell biology in normal and patho
图书封面Titlebook: Schwann Cell Development and Pathology;  Kazunori Sango,Junji Yamauchi Book 2014 Springer Japan 2014 Axonal degeneration.Coculture systems.
描述.This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot–Marie–Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies have allowed us to investigate the pathobiology of Schwann cells in vivo and. .in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron–Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs
出版日期Book 2014
关键词Axonal degeneration; Coculture systems; Demyelination; Myelin sheath; Neuroglia; Neuron–Schwann cell inte
版次1
doihttps://doi.org/10.1007/978-4-431-54764-8
isbn_softcover978-4-431-56370-9
isbn_ebook978-4-431-54764-8
copyrightSpringer Japan 2014
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发表于 2025-3-21 21:01:07 | 显示全部楼层
deep insights into Schwann cell biology in normal and patho.This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot–Marie–Tooth diseases, amyloi
发表于 2025-3-22 02:06:25 | 显示全部楼层
Introduction, peripheral nervous system. The abnormalities of Schwann cells and their crosstalk with neurons lead to peripheral nerve disorders, such as Charcot-Marie-Tooth disease, immune-mediated neuropathy, amyloid polyneuropathy, and diabetic neuropathy. In this book, we summarize recent topics on the biolog
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Charcot-Marie-Tooth Disease,disease is divided into demyelinating type (CMT1, with autosomal dominant inheritance, and CMT4, with autosomal recessive inheritance), axonal type (CMT2, including both autosomal dominant and autosomal recessive inheritance), and combined type (dominant-intermediate CMT). To date, more than 40 gene
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Node of Ranvier Disruption: A Key Pathophysiology in Immune-Mediated Neuropathies,evidence demonstrates that disruption of nodal Na. channel clusters is the key pathophysiology in immune-mediated neuropathies such as Guillain–Barré syndrome. Autoimmune attack against either axons or myelin can disturb neuron–Schwann cell interactions at and near nodes, disrupting Na. channel clus
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