Titlebook: Sandostatin® in the Treatment of Acromegaly; Consensus Round Tabl Steven W. J. Lamberts Conference proceedings 1988 Springer-Verlag, Berlin

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agenda

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Bromocriptine Treatment of Acromegaly,urgery the accepted therapy of choice in acromegaly, followed by high voltage radiotherapy [5, 7, 15, 19]. However, though this has led to considerable improvement of therapeutical results, acromegaly is still a “stubborn therapeutic challenge” as Daughaday pointed out 17 years ago [4]. Thus medical

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,Studies on the Acute and Chronic Effects of Sandostatin® in Acromegaly,)secretion. Studies using cultured tumor cells prepared from the GH-secreting pituitary adenomas of acromegalic patients, showed that hormone secretion by these cells has retained qualitatively a high sensitivity to the inhibitory effect of somatostatin and to the stimulatory effect of GHRH [10]. On

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,Treatment of Acromegaly with the Somatostatin Analogue SMS 201–995 (Sandostatin®),ts efficacy and long-term usefulness in 12 patients with therapy-resistant disease. All had been previously treated by transsphenoidal surgery, irradiation, bromocriptine or a combination of these but their GH concentrations had been insufficiently lowered. Duration of Sandostatin treatment was at l