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Titlebook: Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs; Proceedings of the I K. D. Rainsford,M. C. Powanda Conference proceedi

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书目名称Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs
副标题Proceedings of the I
编辑K. D. Rainsford,M. C. Powanda
视频video
图书封面Titlebook: Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs; Proceedings of the I K. D. Rainsford,M. C. Powanda Conference proceedi
描述The availability of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) sold over-the-counter (OTC) to the public without prescription has become an issue of major concern in recent years. The problem has been highlighted in the UK, USA and other countries because of the continuing high rates of cases of poisoning and the influence of switching from prescription-only status for many NSAIDs to OTC sale brought about, in a large part, by governments and health maintenance organisations (especially in the USA) anxious to save on costs of these drugs. Concern in the UK about poisoning from paracetamol and the appreciable morbidity and mortality from aspirin was such that a major review was initiated in 1996 by the UK government‘s Medicines Control Agency (MCA). Doubtless, many other governments have also undertaken reviews of the safety issues concerning OTC analgesics and NSAIDs. In the UK the situation has culminated in the decision announced in August 1997, as this book was going to press, that the number of tablets/capsules of the solid dosage forms of paracetamol and aspirin would be limited for sale OTe. This decision was essentially based on the need to limit the unit
出版日期Conference proceedings 1998
关键词Alzheimer; analgesics; cancer; clinical trial; drug; kinetics; metabolism; pain; pharmacokinetics; research; s
版次1
doihttps://doi.org/10.1007/978-94-011-4878-8
isbn_softcover978-94-010-6044-8
isbn_ebook978-94-011-4878-8
copyrightSpringer Science+Business Media New York 1998
The information of publication is updating

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Review of Published Clinical Trial Data on the Adverse Reactions from Ibuprofen and Paracetamol/Acetle objective information is available on the safety of both these drugs even though the general perception is that they are considered safe. Thus, we undertook an analysis of literature reports of adverse events from OTC doses of those published since 1981 in clinical trials. The results showed tha
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Acute Human Toxicity from NSAIDs and Analgesics,missions and many of the deaths from drug overdosage. At the same time, since analgesics have a well established role in self-medication, it is important to consider their toxicity in acute overdosage as a part of safety profile of OTC drugs.
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Regulatory Considerations Concerning Safety of OTC NSAIDs and Analgesics,as persons consulting physicians, pharmacists, or other professionals for treatment, and, importantly, for diagnosis). This recourse contains several implications: the individual regards the symptom as minor or non-threatening and is willing to temporize to see if the problem can disappear on its ow
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Evaluation of Analgesic Mechanisms and NSAIDs for Acute Pain Using the Oral Surgery Model,rapolated to the treatment of acute pain following other forms of minor surgery and the use of analgesics for acute pain in ambulatory patients. The oral surgery model [1] has been used extensively over the past 20 years to evaluate the effects of NSAIDs, opioids, steroids, and other classes of drug
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Multicentre Study of the Efficacy of Ibuprofen Compared with Paracetamol in Throat Pain Associated ults from these models to the painful conditions for which patients are most likely to self-medicate. Schachtel [1] has previously published details of a sore throat model for evaluating OTC analgesics and it was of interest to validate this model in a multicentre setting in France. Thus, the object
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