Titlebook: STAT Inhibitors in Cancer; Alister C. Ward Book 2016 Springer International Publishing Switzerland 2016 Alternate inhibitors.Cancer Etiolo

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2196-9906 to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials..978-3-319-82701-8978-3-319-42949-6Series ISSN 2196-9906 Series E-ISSN 2196-9914

Shuttle

STATs in Health and Disease, to mediate a diverse range of functions. This chapter provides an overview of the STAT protein family, their structure, mode of activation, specificity, variants and negative regulation along with their multiple roles in both normal biology as well as the etiology of disease.

Mast-Cell

Inhibitors of Upstream Inducers of STAT Activation,s or small molecules and so represent attractive candidates for therapeutic development. This chapter details several promising agents that target receptors — both receptor tyrosine kinases and cytokine receptors — and downstream kinases that activate STATs in cancer, including EGFR, VEGFR, IL-6R, SRC and ABL.

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hieroglyphic

978-3-319-82701-8Springer International Publishing Switzerland 2016

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Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/s/image/860348.jpg