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Titlebook: Rubidomycin; A New Agent against J. Bernard,R. Paul,R. Maral Book 1969 Springer-Verlag Berlin Heidelberg 1969 alkaloids.antibiotics.cancer

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书目名称Rubidomycin
副标题A New Agent against
编辑J. Bernard,R. Paul,R. Maral
视频video
丛书名称Recent Results in Cancer Research
图书封面Titlebook: Rubidomycin; A New Agent against  J. Bernard,R. Paul,R. Maral Book 1969 Springer-Verlag Berlin Heidelberg 1969 alkaloids.antibiotics.cancer
描述Trials in the treatment of the leukemias are sometimes based on a hypothesis, as in the case of exchange transfusion [33] or the use of antimetabolites [86]. Or they are conducted empirically as the results of chance observations, as in the case of the use of the nitrogen mustards, urethane, and the Vinca alkaloids. Or they lie between the two, aiming at making use of well established biological facts: examples are the use of ACTH, cortisone and, more recently, the antibiotics. What is true for bacteria may also perhaps be true, if not for elephants, at least for the malignant cells of mammals. It was this idea that lay behind the first attempts at treating cancer and leukemia with antibiotics. The results obtained by the use of certain substances extracted from micro-organisms (actinomycin, azaserine, mito­ mycin, rufocromomycin), although encouraging at times, were inconsistent. The action of rubidomycin appears to cover a wider spectrum and to be more consistent and more effective. As in the case of Homer and Christopher Columbus, the honor of having given birth to rubidomycin is claimed by more than one country and town. In fact, the same product was discovered in the same year
出版日期Book 1969
关键词alkaloids; antibiotics; cancer; leukemia
版次1
doihttps://doi.org/10.1007/978-3-642-88125-1
isbn_softcover978-3-642-88127-5
isbn_ebook978-3-642-88125-1Series ISSN 0080-0015 Series E-ISSN 2197-6767
issn_series 0080-0015
copyrightSpringer-Verlag Berlin Heidelberg 1969
The information of publication is updating

书目名称Rubidomycin影响因子(影响力)




书目名称Rubidomycin影响因子(影响力)学科排名




书目名称Rubidomycin网络公开度




书目名称Rubidomycin网络公开度学科排名




书目名称Rubidomycin被引频次




书目名称Rubidomycin被引频次学科排名




书目名称Rubidomycin年度引用




书目名称Rubidomycin年度引用学科排名




书目名称Rubidomycin读者反馈




书目名称Rubidomycin读者反馈学科排名




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https://doi.org/10.1007/978-3-642-88125-1alkaloids; antibiotics; cancer; leukemia
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History of RubidomycinAlthough short, the history of rubidomycin can be divided into three periods.
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Biological ActivityThe choice of constituent A, i. e. rubidomycin, for use in chemotherapy [164, 165] was based on its greater stability, the fact that it could be obtained in the crystalline state [62] and, as found, in particular, with mice, its higher curative ratio; these factors more than outweighed its lower biological activity in absolute terms.
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Fixation in the Cell and Mechanism of ActionExcept for recent papers by . et al., one of which [67] deals with the . investigation of its metabolization by tissue extracts, the other [65] with blood and urine determinations in the animals treated, no work has been published, as far as we know, on the analysis of rubidomycin in animal tissues.
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PosologyRubidomycin can be used alone or in association with other drugs. The dose varies according to the disease and according to the stage of the disease, the details being given elsewhere for each of the main therapeutic indications. We shall confine ourselves here to some general remarks.
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