Titlebook: Role of the Choroid Plexus in Health and Disease; Jeppe Praetorius,Bonnie Blazer-Yost,Helle Damkier Book 2020 The American Physiological S

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Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics, (CP) ion transport and CSF flow dynamics. Hugh Davson, Malcolm Segal, Michael Bradbury, Michael Pollay, Keasley Welch, Helen Cserr, John Pappenheimer, and colleagues, developed laboratory preparations to assess tracer uptake/release by CP and associated flow dynamics within the ventricular-brain sy

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Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals, and the availability of these membranes allows detailed studies of relevant transport mechanisms. Here we review data from amphibians and relate them to mammals. Osmotic water permeabilities have been determined in amphibians with high precision by means of microelectrodes. No significant unstirred

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Acid/Base Transporters in CSF Secretion and pH Regulation,transporters and carbonic anhydrase. In fact, the CO./HCO.. buffer system is required for effective CSF secretion. Unlike blood, the CSF contains very little protein and yet it responds efficiently to changes in pH utilizing primarily the CO./HCO.. buffer system. Besides a central role in CSF secret

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TRPV4, a Regulatory Channel in the Production of Cerebrospinal Fluid by the Choroid Plexus, TRPV4 is activated and regulated by a wide variety of endogenous and exogenous stimuli. In addition to its relatively ubiquitous distribution and regulation by diverse stimuli including pressure, pH, inflammation, cell swelling and cytokines, TRPV4 appears to be a hub protein in many signaling casc