Titlebook: Role of Proteases in Cellular Dysfunction; Naranjan S. Dhalla,Sajal Chakraborti Book 2014 Springer Science+Business Media New York 2014 an

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Book 2014 a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can

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2512-2142 nction, with strong emphasis on identifying proteases and th.It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to s

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Role of Calpain in Immunobiology of Neurodegenerative Diseases the central nervous system (CNS). Studies from our laboratory and other laboratories clearly indicate that calpain plays crucial roles in pro-inflammatory immune responses to perpetuate inflammation in multiple sclerosis (MS), which is a demyelinative and neurodegenerative disease of the CNS, and e

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Proteases and Cancer Developmente development of cancer are discussed in this chapter. As mitochondrial proteases, HtrA2/Omi regulates inhibitors of apoptosis proteins, while Lon protease degrades misfolded proteins and maintains the stability of the mitochondrial genome. Caspases are closely interconnected with mitochondria in ap

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