Titlebook: Risk and Progression Factors in Carcinogenesis; H. K. Müller-Hermelink,H.-G. Neumann,W. Dekant Conference proceedings 1997 Springer-Verlag

极端的正确性

Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines are explained by the formation of metabolites that react with macromolecules by forming adducts (Kriek 1969; Franz et al. 1986). DNA adducts may cause mutations which are responsible for tumorigenic effects. Results from comparative studies, however, indicate that tissue-specific and species-specif

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Xiphophorusher aspect of turmorigenesis, namely the involvement of genetic factors in the processes that lead to malignant tumors. It is becoming evident that both the noxious influences in the environment and the genetic makeup of cells or of the whole individual are involved in cancerous processes to a simil

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Saccharomyces cerevisiaeonstrated that many protooncogenes take part in the regulation of cell growth. Pradl, for instance, has been identified as cyclin Dl. Myc is involved in early cell cycle events while p53, one of the growing number of tumor suppressors, blocks the cell cycle in Gl in response to DNA damage. These pro

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0080-0015 ular growth control and increase invasive and metastatic properties. This book focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogens with cellular DNA in experimental tumors and cell lines to the analysis of selected human tumors. Special

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Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites anhe genetic events contributing to human cancers. However, new techniques make it possible to evaluate these events in both human and model systems and should aid in evaluating the appropriateness of any particular assay in predicting the disease in humans.

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