Titlebook: Reviews of Physiology, Biochemistry and Pharmacology 159; S.G. Amara,E. Bamberg,R. Zechner Book 2007 The Editor(s) (if applicable) and The

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The profile of profilins,y conserved. However, their precise role in regulating actin-related functions is just beginning to emerge. This article recapitulates the wealth of information on structure, expression and functions accumulated on profilins from many different organisms in the 30 years after their discovery as acti

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,Assigning functions to genes—the main challenge of the post-genomics era,sm in healthy and disease states. A huge number of gene products await functional characterization. Hence, there is a strong demand for technological solutions that help to assign the functions of proteins and genes. This review discusses high-throughput molecular biology methods, which promise to meet the challenges of the post-genomic era.

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The profile of profilins,n-binding proteins. Emphasis is given to their interaction with a plethora of many different ligands in the cytoplasm as well as in the nucleus, which is considered the basis for their various activities and the significance of the tissue-specific expression of profilin isoforms.

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Polyphenols and cancer cell growth,finally, direct or indirect interactions with nucleic acids and nucleoproteins. These actions involve almost the whole spectrum of basic cellular machinery—from the cell membrane to signaling cytoplasmic molecules and to the major nuclear components—and provide insights into their beneficial health

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