Titlebook: Reviews of Physiology, Biochemistry and Pharmacology; Volume: 127 Book 1996 The Editor(s) (if applicable) and The Author(s), under exclusi

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Reviews of Physiology, Biochemistry and Pharmacology978-3-540-49453-9Series ISSN 0303-4240 Series E-ISSN 1617-5786

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Reviews of Physiology, Biochemistry and Pharmacologyhttp://image.papertrans.cn/r/image/829641.jpg

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Biosynthesis of nitric oxide: Dependence on pteridine metabolism,. Cytokine or drug-mediated increase in intracellular tetrahydrobiopterin, in contrast, stimulates NO formation and hence NO-mediated effects on the cells. Two of these effects have been detailed here, the activation of soluble guanylyl cyclase by binding of NO to its heme group and the regulation of iron metabolism by interaction with IRP.

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Biosynthesis of nitric oxide: Dependence on pteridine metabolism,or full activity. The precise role of tetrahydrobiopterin is unknown, but several lines of evidence support the hypothesis of a role in redox catalysis in addition to allosteric activation. In cultured cells, depletion of intracellular tetrahydrobiopterin can limit NO formation by all three isozymes

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Analyzing the Function of Essential Genes by Plasmid Shufflingeloped over the years to identify essential genes. Here, we describe an implemented plasmid shuffling method useful to assess the essentiality of overlapped genes under very stringent conditions. A host strain harboring the chromosomal deletion of the genes of interest is complemented by a thermosen

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