Titlebook: Reverse Engineering of Regulatory Networks; Sudip Mandal Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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Implementation of Exome Sequencing to Identify Rare Genetic Diseases,netic disorders. Recent advances in NGS tools and techniques have led to accurate and timely diagnosis of a large proportion of genetic diseases by finding sequence variations in clinical samples. One of the NGS techniques, exome sequencing (ES), is considered as a powerful and easily approachable m

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New Insights into Clinical Management for Sickle Cell Disease: Uncovering the Significant Pathways emolysis, and vasculopathy has been established, hemoglobin polymerization, which results in erythrocyte stiffness and Vaso-occlusion, is important to the pathophysiology of this disease. Clinical management is elementary, and there is scant reliable data for many treatments. The onset of cerebrovas

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Identification of Culprit Genes for Different Diseases by Analyzing Microarray Data,Microarray analysis is one such powerful method that is widely used to identify genes that are expressed differently in two or more conditions (disease vs. normal). Because of its large library of statistical R packages and user-friendly interface, the R programming language provides a platform for

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Prediction and Analysis of Transcription Factor Binding Sites: Practical Examples and Case Studies cting with the transcriptional machinery. TFBSs are typically located upstream of target genes, within a few thousand base pairs of the transcription start site. The binding of TFs to TFBSs influences the recruitment of the transcriptional machinery, thereby regulating gene transcription in a precis

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Hubs and Bottlenecks in Protein-Protein Interaction Networks,ular processes, including signal transduction, metabolic regulation, and gene expression. In PPINs, centrality measures are widely used to identify the most critical nodes. The two most commonly used centrality measures in networks are degree and betweenness centralities. Degree centrality is the nu