Titlebook: Retinal and Choroidal Angiogenesis; J.S. Penn Book 2008 Springer Science+Business Media B.V. 2008 Choroidal.Penn.Retinal.angiogenesis.regu

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Growth Factor Synergy in Angiogenesisact synergistically to elicit more potent angiogenic responses in endothelial cells. At the same time, some factors antagonize each other. Possible mechanisms of these phenomena are discussed. Anti-angiogenic strategies for cancer and retinopathies accounting for growth factor interactions are delin

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Animal Models of Choroidal Neovascularizationtherapies to treat it, several experimental animal models of CNV have been developed. The most widely used of these models is laser-induced CNV in primates and rodents, but several knockout and transgenic mouse models exist as well. The aim of this chapter is to explore the historical background and significance of these animal models of CNV.

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Hypoxia Inducible Factor-1 and VEGF Inductionated HIF-1α protein translocates to the nucleus, dimerizes with HIF-1β and activates transcription of several target genes, including VEGF, by binding to the .-acting hypoxia responsive element 5’-A/(G)CGTG-3’.

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