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Titlebook: Retinal Pigment Epithelium in Health and Disease; Alexa Karina Klettner,Stefan Dithmar Book 2020 Springer Nature Switzerland AG 2020 Retin

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RPE and the Vascular Endothelial Growth Factor of RPE-derived VEGF will be discussed, as well as the physiological and induced pathways of VEGF regulation, especially induced by hypoxia, oxidative stress and hyperglycemia, inflammation and hyperthermia.
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The RPE Cell and the Immune Systemunity and autoimmunity, retinal infections and in a variety of retinal degenerative disorders. Understanding the immune regulatory properties of this cell may provide additional clues to disease mechanisms that may lead to future treatments for many human retinal diseases.
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Retinal Pigment Epithelium in Proliferative Disorders chapter we will review various aspects of the effector mechanisms, including their molecular regulation, by which RPE cells contribute to fibrosis, inflammation and angiogenesis in proliferative disease.
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RPE Autofluorescencen and melanolipofuscin. The examination of autofluorescence therefore extends the understanding of pathophysiology of diseases and disease progression. As a result of considerable technical advances, even single intracellular granules can be analysed in detail today. These techniques will become relevant for clinical examinations in the future.
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Retinal Pigment Epithelium in Age-Related Macular Degeneration stress, protein aggregation, and chronic inflammation evoke dysfunctionality of the RPE, which usually starts many years earlier than the patient recognizes visual loss. Here, we discuss about the role of RPE in the pathogenesis of AMD.
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Retinal Pigment Epithelium in Health and Disease: Maturation, Aging and Age-Related Macular Degeneraormation) under appropriate conditions. Furthermore, the differences between natural aging and early signs of affected RPE in disease will be highlighted. The morphological RPE changes in more advanced stages of diseases like age-related macular degeneration include more than a dozen phenotypes, which, finally, will lead to apoptosis and atrophy.
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Book 2020k, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. ..Retinal Pigment Ep
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