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Titlebook: Retinal Degenerative Diseases XIX; Mechanisms and Exper John D. Ash,Eric Pierce,Christian Grimm Conference proceedings 2023 The Editor(s) (

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The Role of Gene Expression Regulation on Genetic Risk of Age-Related Macular Degenerationctional interpretation of several AMD-GWAS loci. This review highlights the knowledge gained to date and discusses future directions to bridge the gap between genetic predisposition and biological mechanisms to reap the full benefits of GWAS findings.
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Elastin Layer in Bruch’s Membrane as a Target for Immunization or Tolerization to Modulate Pathologyly modified by cigarette smoke (ox-elastin) exacerbated ocular pathology and vision loss in CSE mice. In contrast, mice receiving peptide immunotherapy (PIT) with ox-elastin did not lose vision over the smoking period and exhibited a more preserved BrM. Immunization and PIT correlated with humoral i
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High-Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptors Cells and Basal Laminarccumulate in these discrete regions can be further identified and studied to attempt to gain a greater understanding of biological processes occurring in debilitating eye diseases such as age-related macular degeneration (AMD).
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Prime Editing Strategy to Install the , c.828+1G>A Mutationiently generate well-laminated retinal organoids. In this study, we developed an efficient prime editing strategy for the installation of the pathogenic . c.828+1 G>A splice-site mutation underlying our patient’s disease.
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