Titlebook: Retinal Degeneration; Methods and Protocol Bernhard H.F. Weber,THOMAS LANGMANN Book 2013 Springer Science+Business Media, LLC 2013 adeno-as

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Phenotyping of Mouse Models with OCTvirtual cross sections that correlate well with histomorphometric data with the advantage that multiple iterative measurements can be acquired in time line analyses to detect dynamic changes and reduce the amount of animals needed per study.

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Generation of Transgenic , Models of Retinal Degenerationrate and maintain. We have developed an alternative to transgenic rodent models of retinal degeneration using transgenic .. We have optimized this system to allow rapid analysis of transgene effects in primary transgenic animals, thereby providing an alternative to establishing transgenic lines, and

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Analysis of Photoreceptor Degeneration in the Zebrafish ,mple of this disease group is Retinitis pigmentosa (RP), characterized by selective loss of photoreceptor cells. RP can be caused by dominant mutations in key factors of the pre-mRNA processing spliceosome. In these cases, the complex events leading to the RP phenotype can only insufficiently be ana

Exaggerate

Analysis of Optokinetic Response in Zebrafish by Computer-Based Eye Trackingn zebrafish (.) the OKR is well developed at 5 days post fertilization and can be used in the laboratory for screening of visual performance following genetic manipulations or pharmaceutical treatments. Several setups for measurement of the zebrafish OKR have been described. All of them are based on

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Analysis of the , Compound Eye with Light and Electron Microscopyeds in a stereotypical fashion, where epithelial cells of the eye imaginal discs are specified, recruited, and differentiated in a sequential order that leads to the highly precise structure of an adult eye. Even small perturbations, for example in signaling pathways that control proliferation, cell