Titlebook: Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches; Daniel Yuan Qiang‘Wong Book 2018 Spri

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Probing the Platinum(IV) Prodrug Hypothesis. Are Platinum(IV) Complexes Really Prodrugs of Cisplati55:7571–7582, 2012 [.]). As such, the axial ligands confers unique possibilities of tuning the pharmacokinetic parameters such as lipophilicity and solubility as well as the attaching any targeting groups or synergistic co-drugs without altering the cellular mechanism of action of the innate platinu

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Book 2018 which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outco

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2190-5053 e pioneering efforts in the conceptualization and implementaThis thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly t