Titlebook: Resistance to Targeted Therapies in Breast Cancer; Jenifer R. Prosperi Book 2017 Springer International Publishing AG 2017 Targeted Therap

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2196-5501 s used to treat ER+ or Her2+ breast cancers (i.e. Tamoxifen .We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signalin

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Targeting FGFR for the Treatment of Breast Cancer,candidates for any currently approved molecular therapies and they are left with suboptimal, highly cytotoxic chemotherapies as treatment options. Therefore, recent research has focused on identifying the molecular drivers of TNBC and metastatic breast cancer that has undergone subtype switching and

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Targeted Therapies in Breast Cancer,th increased cell proliferation and mammosphere production, while inhibition has been shown to minimize these effects in cancerous cells. The PI3K pathway is an essential component of intracellular signaling that is frequently dysregulated in tumors. Poly(ADP-ribose) polymerases (PARP) are implicate

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Future Paradigm of Breast Cancer Resistance and Treatment, a resistant cell. One of the examples of these molecularly targeted biomarker therapies in HER2/neu-positive breast cancer is HER2/neu blockage. Following endocrine therapy, the occurrence of secondary resistance, such as ESR1 mutations, poses a significant challenge. Drugs like lapatinib may be ef

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