| 书目名称 | Resistance to Aromatase Inhibitors in Breast Cancer |
| 编辑 | Alexey Larionov |
| 视频video | |
| 概述 | Brings together the current knowledge of molecular and translational aspects of AIs resistance in breast cancer.Provides mechanisms of physiological resistance and potential biomarkers that recognize |
| 丛书名称 | Resistance to Targeted Anti-Cancer Therapeutics |
| 图书封面 |  |
| 描述 | Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients w |
| 出版日期 | Book 2015 |
| 关键词 | aromatase protein; breast cancer; estrogen receptor; genetic polymorphism; oestrogens; antibacterial drug |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-17972-8 |
| isbn_softcover | 978-3-319-38284-5 |
| isbn_ebook | 978-3-319-17972-8Series ISSN 2196-5501 Series E-ISSN 2196-551X |
| issn_series | 2196-5501 |
| copyright | Springer International Publishing Switzerland 2015 |
发表于 2025-3-21 16:15:34
