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Titlebook: Resistance of Targeted Therapies Excluding Antibodies for Lymphomas; Andrés J. M. Ferreri Book 2018 Springer International Publishing AG,

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书目名称Resistance of Targeted Therapies Excluding Antibodies for Lymphomas
编辑Andrés J. M. Ferreri
视频video
概述This book will focus on recently developed targeted therapies other than monoclonal antibodies used in lymphoma patients, both in routine practice and investigative trials.Divided by groups of drugs,
丛书名称Resistance to Targeted Anti-Cancer Therapeutics
图书封面Titlebook: Resistance of Targeted Therapies Excluding Antibodies for Lymphomas;  Andrés J. M. Ferreri Book 2018 Springer International Publishing AG,
描述.In the last decade, the literature on molecular mechanisms and activated pathways in the different lymphoma categories increased exponentially, which was followed by a more diffuse and successful use of targeted therapies. In this book, expert authors revisit the most relevant aspects of these therapies, with special emphasis on molecular mechanisms and clinical effects of resistance. The knowledge of the underlying mechanisms involved in tumor resistance to target therapies is of paramount importance because they will result in a better selection of patients with sensitive disease and the establishment of suitable combinations of drugs that target different molecules and could overcome the established resistance..
出版日期Book 2018
关键词Lymphomas; Malignancies; Investigative trials; Resistance; Relapse
版次1
doihttps://doi.org/10.1007/978-3-319-75184-9
isbn_softcover978-3-030-09165-1
isbn_ebook978-3-319-75184-9Series ISSN 2196-5501 Series E-ISSN 2196-551X
issn_series 2196-5501
copyrightSpringer International Publishing AG, part of Springer Nature 2018
The information of publication is updating

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Book 2018resistance to target therapies is of paramount importance because they will result in a better selection of patients with sensitive disease and the establishment of suitable combinations of drugs that target different molecules and could overcome the established resistance..
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Proteasome Inhibitors with a Focus on Bortezomib, patients eventually have progressive disease and development resistance to treatment. Multiple unique mechanisms of resistance have been identified, and they are unified by reducing a cell’s sensitivity to endoplasmic reticulum stress either from changes intrinsic to the cancer cell or extrinsic to
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mTOR Inhibitors, with Special Focus on Temsirolimus and Similar Agents,Ks). Dysregulation of mTOR signaling is associated with the development of cancers, including myeloid and lymphoid malignancies. Here, we will provide a brief overview of mTOR inhibitors and discuss the results obtained using these compounds in hematologic malignancies and especially in lymphomas. M
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