Titlebook: Research in Computational Molecular Biology; 18th Annual Internat Roded Sharan Conference proceedings 2014 Springer International Publishin

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0302-9743 ECOMB 2014, held in Pittsburgh, PA, USA, in April 2014. The 35 extended abstracts were carefully reviewed and selected from 154 submissions. They report on original research in all areas of computational molecular biology and bioinformatics.978-3-319-05268-7978-3-319-05269-4Series ISSN 0302-9743 Ser

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MRFalign: Protein Homology Detection through Alignment of Markov Random Fields,ry short-range residue correlation, but not long-range residue interaction. However, remote homologs may have very divergent sequences and are only similar at the level of (long-range) residue interaction pattern, which is not encoded in current popular PSSM or HMM models.

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On the Representation of de Bruijn Graphs,approaches. As part of ., we develop the notion of frequency-based minimizers and show how it can be used to enumerate all maximal simple paths of the de Bruijn graph using only 43 MB of memory. Finally, we demonstrate that our approach can be integrated into an existing assembler by modifying the ABySS software to use ..

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PASTA: Ultra-Large Multiple Sequence Alignment,are highly accurate – slightly better than SATé trees, but with substantial improvements relative to other methods. Finally, PASTA is very fast, highly parallelizable, and requires relatively little memory.

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Conference proceedings 2014, held in Pittsburgh, PA, USA, in April 2014. The 35 extended abstracts were carefully reviewed and selected from 154 submissions. They report on original research in all areas of computational molecular biology and bioinformatics.

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