Titlebook: Research in Computational Molecular Biology; 15th Annual Internat Vineet Bafna,S. Cenk Sahinalp Conference proceedings 2011 Springer Berlin

玩忽职守

A Probabilistic Model for Sequence Alignment with Context-Sensitive Indels,ent studies have shown a significant correlation between the content of short indels and their flanking regions, which by definition cannot be modelled by the above two approaches. In this work, we present a context-sensitive indel model based on a pair Tree-Adjoining Grammar (TAG), along with accom

微枝末节

Simultaneous Structural Variation Discovery in Multiple Paired-End Sequenced Genomes,ted rate, making the initiation of large scale projects aiming to sequence almost 2000 genomes [1]. Structural variation detection promises to be one of the key diagnostic tools for cancer and other diseases with genomic origin. In this paper, we study the problem of detecting structural variation e

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CLAY

malapropism

尾随

Pedigree Reconstruction Using Identity by Descent,viduals are related is a very time-consuming and expensive process. Methods for automating the construction of pedigrees could stream-line this process. While constructing single-generation families is relatively easy given whole genome data, reconstructing multi-generational, possibly inbred, pedig

heterogeneous

A Quantitative Model of Glucose Signaling in Yeast Reveals an Incoherent Feed Forward Loop Leading ed biological components. Surprisingly, few validated kinetic models of complex regulatory networks have been derived by combining models of the network components. A major bottleneck in producing such models is the difficulty of measuring in vivo rate constants for components of complex networks. W

预知

假设

IsoLasso: A LASSO Regression Approach to RNA-Seq Based Transcriptome Assembly,s. One of them is transcriptome assembly based on RNA-Seq data, which aims at reconstructing all full-length mRNA transcripts simultaneously from millions of short reads. In this paper, we consider three objectives in transcriptome assembly: the maximization of ., minimization of ., and maximization

FUSC

Haplotype Reconstruction in Large Pedigrees with Many Untyped Individuals, human traits. However haplotypes are not directly available from current genotyping platforms, and hence there are extensive investigations of computational methods to recover such information. Two major computational challenges arising in current family-based disease studies are large family sizes